Hootsuite is web based, so whether I'm in my regular location, at home or on the go, my settings are EXACTLY the same. With Seesmic I had to transport a settings file with me and install the software on each machine I was going to use it on. With Hootsuite, since it's web based there is no need for that. Yes I know, other apps including Seesmic have a web based client. But Hootsuite has done a really nice job on theirs. You can have multiple accounts, as well as multiple people tweeting with different access depending on what you want them to do. It's like combining the best web twitter clients with something like cotweet.com.
In Hootsuite I have multiple accounts setup for twitter as well as LinkedIn, Facebook, and Foursquare. I have many columns in each twitter account which includes lists I follow and searches. Searches are a problem I found with Seesmic, they weren't updating correctly. I also found that Seesmic lists didn't update correctly in their .NET client. I reported both these problems to Seesmic, and although their team is very good, it seems they were concentrating more on mobile applications than the desktop clients.
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